Why D-neuron? Direction from Psychiatric Research

Why D-neuron? Importance in schizophrenia research

Recent pharmacological discovery on trace amineassociated receptor, type 1(TAAR1) has emphasized importance of trace amines in pathogenesis of psychoses, such as schizophrenia. TAAR1 has many ligands, including tyramine, β-phenylethylamine (PEA), amphetamines, and 3’-iodothyronamine. Socalled D-neurons are putative producer of trace amines, endogenous ligands of TAAR1. The D-neuron is defined “...

PM494. So-called D-neuron (trace amine neuron) is a new clue for schizophrenia research: From therapeutic direction

So-called D-neuron (trace amine (TA) neuron) is the ligand neuron of trace amine-associated receptor, type 1 (TAAR1). Reduced stimulation of TAAR1 on dopamine (DA) neurons in the midbrain ventral tegmental area (VTA) has been revealed to increase firing frequency of VTA DA neurons. A Patent Cooperation Treaty (PCT)-required histochemical methods (K. Ikemoto) were used to specify subgroups of D-...

Perspective of D-Neuron (Trace Amine Neuron) Research: From Novel Therapeutic Strategies

Recent pharmacological studies have shown the importance of trace amine-associated receptor, type 1 (TAAR1), a subtype of trace amine receptors, to be a prospective target receptor for novel neuroleptics. Socalled D-neuron (trace amine (TA) neuron) is the ligand neuron of TAAR1. In 1984, Jaeger et al. specified D-neuron groups from D1 (the spinal cord) to D14 (the bed nucleus of stria terminali...

Why the excess mortality from psychiatric illness?

Psychiatric Research

One of the important ways to enhance knowledge and understanding about psychiatric illness and their management is through research. Psychiatric research has kept is due important position in psychiatric practice since last many decades. Without research it might be impossible to appropriately manage any given psychiatric case with proper rationale. The significance of research in psychiatry is...